In 2020, scientists around the world began researching Covid19. Since the scope of cannabis and cannabinoids in recent years became popular and very well-researched and professionally evaluated, some of the research became dedicated to the link between cannabinoids and the Sars-CoV2 virus and the disease Covid19.

In a study from 2021 Nguyen and colleagues described that CBD can block Sars-CoV2 infection in the early stages of infection and that cannabinoid use is associated with a lower risk of infection, and that the active compound 7-OH-CBD, which is the same metabolite that is also involved in the treatment of epilepsy with CBD. They described a significant reduction in the risk of virus infection in patients taking CBD. Although many CBD formulations are available on the market, they vary widely in quality, quantity, and pharmacokinetic properties after oral administration.

In an article from 2020, Esposito and his colleagues investigated the impact of potential pandemic diseases cannabidiol Covid19. Phytocannabinoid CBD is one of the most interesting molecules in the field of pharmacology, as it has a wide range of therapeutic effects, among which are proven anticonvulsant, sedative, hypnotic, antipsychotic, anti-cancer, anti-inflammatory and neuroprotective. It is believed that cannabidiol and other cannabinoids promising drug candidates, which could bet on the encouraging preclinical studies. Further research and evidence will be needed to confirm the beneficial properties in the use of cannabinoids for the treatment of Covid-19 disease.

In a 2021 study, Raj and colleagues investigated the antiviral properties of cannabinoids against the virus using computer simulations and an in vitro approach. They performed a structured review of various cannabinoids because they directly or indirectly activate the CB2 receptor and weaken the properties of inflammatory cytokines. Based on a computer study and the in vitro antiviral potentials of CBD and d9-THC against Sars-CoV2, it was concluded that both molecules can inhibit the virus in two ways. The molecules can bind to and inhibit SARS-CoV-2 M ^pro , leading to blockage of the translation process and reduction of inflammatory cytokine levels in lung cells by acting as a CB2 receptor agonist. Thus, CBD and d9-THC can be used in combination with each other or with other drugs to treat patients with Covid-19.

In addition to the above-mentioned research and studies, a large number of articles are available exploring the effects and possibilities of using cannabinoids to alleviate the course of the disease, as a preventive protection, and as a successful aid in the treatment and elimination of consequences after illness.