{"id":9487,"date":"2021-11-30T14:15:53","date_gmt":"2021-11-30T13:15:53","guid":{"rendered":"https:\/\/www.hempethica.com\/?p=9487"},"modified":"2021-12-23T10:03:11","modified_gmt":"2021-12-23T09:03:11","slug":"luskavica-in-pomoc-s-kanabinoidi","status":"publish","type":"post","link":"https:\/\/www.hempethica.com\/en\/luskavica-in-pomoc-s-kanabinoidi\/","title":{"rendered":"Psoriasis and help with cannabinoids"},"content":{"rendered":"
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Psoriasis<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Psoriasis is a complex chronic inflammatory skin disease with aberrant immunopathogenetic mechanisms. The pathogenesis includes hyperkeratotic plaques, usually localized on the scalp, elbows, knees and buttocks, and are characterized by cutaneous inflammatory infiltrates, epidermal hyperplasia and impaired keratinocyte differentiation, and hypervascularity in the upper skin (epidermis \/ dermis). Clinically, it manifests as redness and peeling. Psoriasis is quite common and affects about 2% of the general population. It is more common in the white population and has a bimodal age distribution, with a maximum incidence between 20 and 30 years and between 50 and 60 years.<\/p>

The molecular mechanisms involved in psoriasis are not yet fully understood. Scientists in the field agree that the disease involves a variety of immune cells, including dendritic cells, Th1 and Th17 lymphocytes, which interact with keratinocytes. Psoriasis can be explained by immune dysregulation against Th1\/Th17 differentiation, which plays a key role in disease development.<\/p>

The cause of psoriasis is multifactorial with genetic and environmental components. Usually (but not always) a family history can be determined. If one parent has psoriasis, the risk of this disorder in a child is about 14%. This figure jumps to 41% if both parents have been diagnosed.<\/p>

In most cases, psoriasis develops in a mild to moderate form. It most commonly occurs in outbreaks where improvement and deterioration alternate. Existing forms of treatment include primarily topical treatment and phototherapy, systemic drugs, or a combination of different therapeutic categories for advanced cases. Environmental factors involved in triggering psoriasis or psoriatic outbreaks include physical trauma (isomorphic or Koebner phenomenon), infections (streptococcal pharyngitis), hypocalcemia, stress, and medications such as lithium, beta blockers, antimalarials, and corticosteroids, and so on.<\/p>

Research into psoriasis began around 1950, before that only its descriptions appear in the literature. After 1950, however, the professional literature on this topic began to appear and is growing exponentially from year to year to this day.<\/p>

Risk factors for psoriasis are not yet fully understood and future studies should successfully establish preventive approaches for psoriasis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Types of psoriasis<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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We know several different types of psoriasis. Some species are more pronounced in mild form and some in moderate or severe form. About 90% of patients get the chronic <\/strong> form. Changes in the skin are visible in the form of plaques and can occur anywhere on the body. They are usually symmetrical in shape, the scales are usually pink. The \u2018droplet\u2019<\/strong> form usually occurs in the younger population, where changes in the skin are visible as tiny scaly bumps. Usually, changes in the skin are visible mainly on the torso. Pustular <\/strong> psoriasis is characterized by the appearance of pus-filled lumps that appear locally. The inverse <\/strong> form of psoriasis is more common in women. Changes in the skin occur mainly in the folds of the joints, under the armpits, in the genital area and buttocks. The erythrodermic <\/strong> form is characterized by redness with associated peeling of the skin.<\/p>

Psoriatic arthritis or inflammation of the joints also joins psoriasis in 30 percent of patients. The joints of the toes and feet are usually affected. Those with a more severe form of psoriasis are usually more susceptible, but it is also becoming more common in patients treated with systemic corticosteroids. An increasingly common side effect is depression, which occurs in some patients with lower self-esteem.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Treatment<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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There are several types and options for treating psoriasis. Approximately 65-70% of patients have a mild form, approx. 20-25% of patients have a moderate form, and approx. 5-10% have a more severe form.<\/p>

In classical medicine, mild forms<\/strong> of topical treatment are most commonly used and include topical medications (creams and ointments). About three-quarters of patients have a milder form of psoriasis, where visible changes are limited to a smaller area of \u200b\u200bskin. Among topical drugs, topical corticosteroids are mainly used. The effect of the treatment is quickly seen, but it is also important to be aware that corticosteroids thin the skin and long-term use can do more harm than good. Hydrocortisone (mild), alcomethasone (moderate) and betamethasone (a strong medicine) are mainly used. Keratolytics are another type of drug used to treat mild forms. These are preparations with salicylic acid or urea, which remove scales that appear on the skin. This also makes other medicines more accessible to the inside of the skin. The third group of drugs includes preparations with vitamin D3 analogues, which inhibit epidermal thickening and trigger normal differentiation and have an immunomodulatory effect. The effects of these drugs do not appear immediately, but only after some time.<\/p>

Phototherapy is also suggested for people with moderate psoriasis<\/strong> and those who are not helped by topical treatment alone. It is a therapy where light improves the condition. UVB light in the range of 290-320 nm is mainly used, which penetrates to the boundary layer between the epidermis and the dermis. Phototherapy has a biological effect, as molecules in the skin (chromophores) absorb light.<\/p>

For the severe form <\/strong> of psoriasis, systemic treatment drugs are used, where retinoid drugs, cyclosporine, methotrexate are used, and biologics, which are a novelty in the field of psoriasis treatment, are increasingly used. These are medicines that are used mainly in cases where all other treatment options have been exhausted. These are specific drugs, where their action is focused primarily on immune mechanisms that cause skin changes in the skin. Biologics have dramatically changed the treatment of psoriasis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Alternative treatment with cannabinoids<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Although there is limited research to confirm the alleged local benefits of cannabinoids, it is certain that skin biology is modulated by the human endocannabinoid system (ECS). Cannabinoid CB1 receptors are present in the nervous system (brain and spinal cord), and CB2 receptors are present primarily in the peripheral nervous system (limb nerves), digestive system, and immune system. Research shows that CB1 receptors like CB2 are also found in epidermal keratinocytes, skin nerve fibers, dermal cells, melanocytes, sweat glands, and hair follicles. Numerous preclinical evidence suggests that topical application of cannabinoids may be effective in some skin conditions such as eczema, psoriasis, pruritus, and various inflammatory conditions. Because ECS has an important regulatory function in the skin, it is very likely that treatment with topical cannabinoids could be effective in certain disorders and skin health in general.<\/p>

At Hempethica, we actively follow and monitor this area. We have some new products that are currently in the testing phase. People who voluntarily participate in our research are testing these new products. Follow us, sign up for our newsletter, and we\u2019ll let you know when our new products are available for free.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Resources:<\/p>

https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/psoriasis<\/a>
Kamiya K, Kishimoto M, Sugai J, Komine M, Ohtsuki M. Risk Factors for the Development of Psoriasis. Int J Mol Sci. 2019 Sep 5;20(18):4347. DOI: 10.3390\/ijms20184347<\/a>. PMID: 31491865; PMCID: PMC6769762.
Langley RG, Krueger GG, Griffiths CE. Psoriasis: epidemiology, clinical features, and quality of life. Ann Rheum Dis. 2005 Mar;64 Suppl 2(Suppl 2):ii18-23; discussion ii24-5. DOI: 10.1136\/ard.2004.033217<\/a>. PMID: 15708928; PMCID: PMC1766861.
Baswan SM, Klosner AE, Glynn K, Rajgopal A, Malik K, Yim S, Stern N. Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders. Clin Cosmet Investig Dermatol. 2020 Dec 8;13:927-942. DOI: 10.2147\/CCID.S286411<\/a>v. PMID: 33335413; PMCID: PMC7736837.
Palmieri B, Laurino C, Vadal\u00e0 M. A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars. Clin Ter. 2019 Mar-Apr;170(2):e93-e99. DOI: 10.7417\/CT.2019.2116. PMID: 30993303. [PubMed]<\/a>
W\u00f3jcik P, Garley M, Wro\u0144ski A, Jab\u0142o\u0144ska E, Skrzydlewska E. Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients. Int J Mol Sci. 2020 Sep 16;21(18):6795. DOI: 10.3390\/ijms21186795<\/a>. PMID: 32947961; PMCID: PMC7554718.
https:\/\/luskavica-psoriaza.si\/<\/a>
https:\/\/sl.wikipedia.org\/wiki\/Luskavica<\/a>
https:\/\/en.wikipedia.org\/wiki\/Psoriasis<\/a>
https:\/\/sl.wikipedia.org\/wiki\/Ko%C5%BEa#Usnjica<\/a>
https:\/\/www.dolenjske-lekarne.si\/strokovni-clanki\/luskavica-bolezen-ki-seze-globoko-pod-kozo<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tShop<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tFind out more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Psoriasis is a complex chronic inflammatory skin disease with aberrant immunopathogenetic mechanisms. The pathogenesis includes hyperkeratotic plaques, usually localized on the scalp, elbows, knees and buttocks, and are characterized by cutaneous inflammatory infiltrates, epidermal hyperplasia and impaired keratinocyte differentiation, and hypervascularity in the upper skin (epidermis \/ dermis). Clinically, it manifests as redness and peeling. <\/p>","protected":false},"author":2,"featured_media":9494,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[68,71],"tags":[59,65,100,67],"class_list":["post-9487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-samozdravljenje","category-kozmeticni-izdelki","tag-cbd","tag-kanabinoidi","tag-luskavica","tag-samozdravljenje"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/11\/Luskavica-Psoriasis-Hempethica.jpg?fit=600%2C600&ssl=1","jetpack-related-posts":[{"id":10881,"url":"https:\/\/www.hempethica.com\/en\/pms-kanabinoidi-samopomoc-lajsanje-bolecin\/","url_meta":{"origin":9487,"position":0},"title":"PMS - Premenstrual Syndrome and help with cannabis","author":"ekipa Hempethica","date":"09\/06\/2022","format":false,"excerpt":"Premenstrual syndrome (PMS) is a cyclical occurrence of certain symptoms. Typical PMS symptoms include back pain, bloating, headaches, irritability and general fatigue. Because cannabinoids affect the EKS by balancing them, and because the concentration of anandamide in the uterus is very high, cannabinoids can also relieve PMS symptoms.","rel":"","context":"In "Samozdravljenje"","block_context":{"text":"Samozdravljenje","link":"https:\/\/www.hempethica.com\/en\/samozdravljenje\/"},"img":{"alt_text":"PMS - Predmenstrualni sindrom in pomo\u010d s kanabinoidi","src":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2022\/06\/PMS-and-CBD.jpg?fit=600%2C600&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2022\/06\/PMS-and-CBD.jpg?fit=600%2C600&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2022\/06\/PMS-and-CBD.jpg?fit=600%2C600&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":7697,"url":"https:\/\/www.hempethica.com\/en\/avtizem-pomoc-s-konopljo-in-kanabinoidi\/","url_meta":{"origin":9487,"position":1},"title":"Autism, cannabinoids and support of cannabis","author":"ekipa Hempethica","date":"07\/07\/2021","format":false,"excerpt":"What is autism? Autism is a complex pervasive developmental disorder with a neurological-biological basis that occurs in childhood. It manifests itself primarily as qualitatively altered behavior in the areas of social interaction, verbal, and nonverbal communication. It covers a wide range of disorders from mild to severe forms.","rel":"","context":"In "Samozdravljenje"","block_context":{"text":"Samozdravljenje","link":"https:\/\/www.hempethica.com\/en\/samozdravljenje\/"},"img":{"alt_text":"Avtizem, Autism, Certificirani produkti Hempethica, WidLab, Certifikati, Vegan, CBD","src":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/07\/Autism-CBD-Hempethica.jpg?fit=600%2C600&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/07\/Autism-CBD-Hempethica.jpg?fit=600%2C600&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/07\/Autism-CBD-Hempethica.jpg?fit=600%2C600&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":10435,"url":"https:\/\/www.hempethica.com\/en\/varnost-konopljinih-izvleckov\/","url_meta":{"origin":9487,"position":2},"title":"Safety in consumption and dosing of cannabis extracts","author":"ekipa Hempethica","date":"19\/01\/2022","format":false,"excerpt":"In general, consumption of cannabis and its extracts is safe and without side effects. At the same time, it should be emphasized that we are mainly talking about cannabinoids, which do not have a psychoactive effect. Of all the cannabinoids we know and have been scientifically proven, there are only three whose side effect is drowsiness.","rel":"","context":"In "Samozdravljenje"","block_context":{"text":"Samozdravljenje","link":"https:\/\/www.hempethica.com\/en\/samozdravljenje\/"},"img":{"alt_text":"Varnost konopljinih izvle\u010dkov","src":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2022\/01\/Varnost-konopljinih-izvleckov.jpg?fit=600%2C600&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2022\/01\/Varnost-konopljinih-izvleckov.jpg?fit=600%2C600&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2022\/01\/Varnost-konopljinih-izvleckov.jpg?fit=600%2C600&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":7879,"url":"https:\/\/www.hempethica.com\/en\/svetovanje-glede-uporabe-kanabinoidov\/","url_meta":{"origin":9487,"position":3},"title":"Consultancy on the use of cannabis and cannabinoids","author":"ekipa Hempethica","date":"29\/07\/2021","format":false,"excerpt":"Konoplja in kanabinoidi? Komu je svetovanje namenjeno? Konoplja in njeni izvle\u010dki so v svetu vedno bolj priznani in postajajo del splo\u0161ne uporabe. Na strokovnem podro\u010dju uporabe kanabinoidov v zdravstvene namene prevladujejo Zdru\u017eene dr\u017eave Amerike, Kanada in Izrael. Konopljo in njene izvle\u010dke dandanes najdemo v razli\u010dnih oblikah. Znanstveno je ena najbolj\u2026","rel":"","context":"In "Samozdravljenje"","block_context":{"text":"Samozdravljenje","link":"https:\/\/www.hempethica.com\/en\/samozdravljenje\/"},"img":{"alt_text":"Svetovanje, Samozdravljenje, ICanna, CBD, kanabinoidi, cannabinoids, hempethica","src":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/07\/Svetovanje-kanabinoidi-CBD-Samozdravljenje-Hempethica.jpg?fit=600%2C600&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/07\/Svetovanje-kanabinoidi-CBD-Samozdravljenje-Hempethica.jpg?fit=600%2C600&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/07\/Svetovanje-kanabinoidi-CBD-Samozdravljenje-Hempethica.jpg?fit=600%2C600&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":7485,"url":"https:\/\/www.hempethica.com\/en\/depresija-in-anksioznost-pomoc-s-konopljo\/","url_meta":{"origin":9487,"position":4},"title":"Depression and anxiety - how can we help ourselves with cannabinoids?","author":"ekipa Hempethica","date":"09\/06\/2021","format":false,"excerpt":"What is depression and anxiety? Did you know that the symptoms of depression and anxiety often intertwined with each other? Cannabinoids and hemp products can significantly alleviate symptoms.","rel":"","context":"In "Samozdravljenje"","block_context":{"text":"Samozdravljenje","link":"https:\/\/www.hempethica.com\/en\/samozdravljenje\/"},"img":{"alt_text":"Depresija in anksioznost, Certificirani produkti Hempethica, WidLab, Vegan, CBD, CBD za \u017eivali, CBD for pets, Energy, Pain Relief, Laj\u0161anje bole\u010din, Kako delujejo kanabinoidi, Endokanabinoidni sistem","src":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/05\/CBD-Pain-Health-benefits-Hempethica.jpg?fit=600%2C600&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/05\/CBD-Pain-Health-benefits-Hempethica.jpg?fit=600%2C600&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.hempethica.com\/wp-content\/uploads\/2021\/05\/CBD-Pain-Health-benefits-Hempethica.jpg?fit=600%2C600&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":7919,"url":"https:\/\/www.hempethica.com\/en\/kanabinoidi-in-covid-19-kako-si-lahko-pomagamo\/","url_meta":{"origin":9487,"position":5},"title":"Cannabinoids and Covid-19 - How can we help our self and each other?","author":"ekipa Hempethica","date":"25\/08\/2021","format":false,"excerpt":"Ali lahko s kanabinoidi zmanj\u0161amo mo\u017enosti oku\u017ebe z virusom Sars-CoV2? 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